Using the linear models in Figures 2C and D (SI Equations S6 and S14), data from multiple SAXS experiments and protein concentrations for all three modulators were fit simultaneously to a one (HFMZ) or two site (CYTZ, TCMZ) models.
The transcription, translation, processing, and secretion of multiple proteins at high concentration are an intrinsically energy-intensive process.
A special feature of NMRdyn is the ability to handle multiple sets of NMR relaxation data at different protein concentrations.
This suggests that regulation by some TFs is accompanied by additional "corrections" or fine-tuning of protein concentrations via combinatorial regulation with multiple miRNAs.
Furthermore, the CXCL5 genotype may in fact be a more stable marker of ACS risk than circulating ENA-78 concentrations since protein concentrations are more likely to be influenced by multiple stress-related factors.
Thus, care should be taken when considering the change in protein concentrations according to stage in a cohort including multiple subtypes.
By multiple regression analysis, however, only IL-6 was independently associated with C-reactive protein concentrations.
Subsequent translocations to the nucleus then result in modulation of multiple gene transcriptions, epigenetic processes and noncoding RNAs with consequent altered translations leading to changes in protein concentrations.
In the cancer patients who had detectable C-reactive protein concentrations (n=41), the relationship between log10 C-reactive protein, log10IL-6, and log10IL-1Ra was examined in multiple linear regression analysis.
Finally, the results of the multiple regression model indicates that serum haptoglobin concentrations are determined in premenopausal women by several factors including BMI, serum C-reactive protein concentrations and the insulin sensitivity index, in addition to haptoglobin genotypes.
