Sentence examples for multiple protein targets from inspiring English sources

Modulating multiple protein targets simultaneously can be beneficial for treating complex diseases.

The biochemical nature of drugs binding to multiple protein targets and its implications on physiology are discussed.

Volatile anaesthetics such as isoflurane, have multiple protein targets, are potent cerebral vasodilators and there exists a narrow range of isoflurane concentrations (<1.5 2%) under which neurovascular coupling is preserved35,36,37.

The emerging PROTAC (Proteolysis Targeting Chimera) technology has been successfully applied to selective degradation of multiple protein targets, but not ALK.

The comprehensive analysis of multiple protein targets has influenced us to make a consensus structural rule exploited by pharmacophore and other allied techniques from a large repository of protein structures.

Since then, it has been applied successfully for multiple protein targets, including GPCRs, for the development of lead compounds with slow dissociation kinetics (i.e. long target residence time) to increase in vivo efficacy or with short residence time to prevent on-target associated side effects.

Staining transfected cells revealed that Cofilin1 knockdown was not sufficient to reproduce the effects on F-actin structures induced by cucurbitacins, consistent with the conclusion that there are multiple proteins targets for these compounds.

The concept that one bacterial species possesses multiple proteins targeting the same ligand is well established.

Given that such a high proportion of cellular proteins are initially translocated into the ER, the ability to co-express multiple proteins targeted to such sites is essential.

Trx is responsible for reducing multiple protein disulfide targets in the cell.

While cytologic and histologic evaluation are the gold standards to detect breast cancer, recent advances in comprehensive molecular technologies allow the simultaneous analysis of multiple protein expression targets.