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Male (NZW x BXSB F1 (W/BF1) mice develop acute systemic autoimmune disease characterized by degenerative coronary vascular disease (CVD) with myocardial infarctions, hypertension, thrombocytopenia, glomerulonephritis, and persistently elevated levels of circulating immune complexes.
The mIL-8Rh chemokine receptor mutant mice develop acute, septic pyelonephritis with about 50% mortality [4], [12], [16].
Furthermore, SALL4 is aberrantly expressed in human acute myeloid leukemia, and transgenic SALL4 mice develop acute myeloid leukemia [27].
These mice develop acute myeloid leukemia with complete penetrance, and have been studied in detail [ 9- 12].
Taken together, these findings clearly indicate that Eμ- HMGA2 transgenic mice develop acute T-cell lymphoblastic leukemia.
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The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with severe tissue damage.
A total of 80%% of male DBA/1 J mice developed acute arthritis around 60 days after CII immunization.
In agreement with previous studies [ 17], 20% of PDLIM2+/+ mice developed acute EAE with a 2.8 mean peak clinical score and a mean disease onset of day 17.3 ± 2.5) of post-immunization with the encephalitogenic PLP180-199 epitope.
When this fusion oncogene is overexpressed in mice via retroviral transduction, the mice consistently develop acute myeloid leukemia [11], whereas tumors with insertions at Evi32 are lymphoblastic lymphomas.
This procedure provokes mice to develop acute myocarditis at 6 to 12 days after injection, and subsequently to proceed to a chronic phase of myocarditis, resulting several weeks later in a DCM phenotype [19].
We investigated whether the mice spontaneously develop acute or chronic pancreatitis.
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mice develop substantial
mice develop significant
mice develop elevated
mice develop early-onset
mice develop extensive
mice develop myasthenic
mice develop high
mice develop glaucoma-like
mice develop local
mice develop pituitary
mice develop spontaneous
mice develop renal
mice develop progressive
mice develop hepatic
mice develop thymic
mice develop systemic
mice develop α-synuclein-dependent
mice develop mild
mice develop complex
mice develop lethal
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