However, upon feeding a 45% high-fat diet, these mice developed elevated fasting blood glucose, glucose intolerance and a β-cell secretion defect.
ET-1+/− heterozygous mice developed elevated BP and mild hypertension, rather than the fall in BP that might have been expected.
In contrast, other studies demonstrated that IL-27R-deficient mice developed elevated Th17 and enhanced central nervous system inflammation when infected with Toxoplasma gondii or induced for experimental autoimmune encephalomyelitis (EAE), implying that IL-27 was an antagonist of Th17 activity [ 84, 85].
Solvent-only-treated mice failed to develop elevated TEWL values above the physiological threshold (A).
Although CYP1B1 knockout mice do not develop elevated IOP, they have abnormalities in their aqueous drainage system, small or absent Schlemm's canal, defects in trabecular meshwork, and peripheral anterior synechia of the iris [ 97].
It is well documented that humans and certain mouse strains can develop elevated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) during respiratory viral infection (Polakos et al., 2006).
We report that germ-free mice and those with low-diversity microbiota develop elevated serum IgE levels in early life.
Arthritis-susceptible DBA/1 mice that are also deficient in the inhibitory receptor FcγRII develop elevated IgG anti-CII levels and enhanced disease.
Studies on transgenic mice showed that mice overexpressing MYOC at a level similar to that induced by steroid use did not develop elevated IOP or glaucoma, 7 8 suggesting that increased MYOC expression alone is not sufficient to cause glaucoma.
We test whether oxidative stress induced by IOP elevation triggers DRP1 and DRP1 S616 phosphorylation-mediated mt fission in the RGC and probe for degeneration in its axon using the glaucomatous DBA/2J (D2) mouse that spontaneously develops elevated IOP.
