However, the mice developed extensive neutrophilia compared to CD40wt/Ldlr−/− (CD40wt) chimeras.
Before the age of 9 months, K5 N1ko mice developed extensive hyperplasia and keratinization of the corneal epithelium, which resulted in opaque plague formation and blindness (Fig. 5B and C) [14].
MGP knock-out mice developed extensive calcification in coronary arteries [ 93].
Histological examination revealed that both BLM-treated wild-type and Scgb3a2-transgenic mice developed extensive pulmonary fibrosis by 3 weeks based on a whole lung H&E stained images (Fig. 2b) and Masson Trichrome staining (Fig. 2c).
At about 12 m.o.a., 3xTg-AD mice also develop extensive neurofibrillary tangles, first in the hippocampus (in particular within pyramidal neurons of the CA1 subfield) and then in the cortex [11].
This mutation is highly fibrillogenic in vivo, and these mice rapidly develop extensive plaque formation (Cheng et al. 2004).
These changes in SOD1 G93Adl mice are in line with our previously published data on the high-copy SOD1 G93A mice, which also develop extensive spinal cord and muscle pathology by late disease stages (Kalmar et al., 2008; Kieran et al., 2004).
The results presented here indicate that EC neurons from mice genetically programmed to develop extensive Aβ and tau pathologies display alterations of intrinsic properties consistent with reduced membrane surface (atrophy) and show increased neuronal activity.
Although Mmp7−/− mice are protected from bleomycin-induced acute lung injury (Li et al., 2002; Manicone et al., 2009), they develop extensive fibrosis, although slightly reduced from that in wild-type mice (Li et al., 2002; Zuo et al., 2002), suggesting a pro-fibrotic role for this protease.
