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The most widely used transgenic mutant SOD1 mouse model develops a very early and aggressive phenotype and, although the mutant mice develop progressive hind limb weakness leading to paralysis and death, with very predictable disease progression (Tu et al., 1996), the accelerated time course of the disease does not accurately reflect the human disease.
MPS VII mice develop progressive lysosomal accumulation of glycosaminoglycans within multiple organs, including the brain.
18 Eventually, Smad3 knockout mice develop progressive illness including leucocytosis, massive inflammation and impaired mucosal immunity.
These mice develop progressive mineralization of the skin, aorta, coronary arteries, and arterial blood vessels in a number of tissues.
FDDKI mice develop progressive synaptic and memory deficits due to loss of mBri2, with no amyloidosis (Tamayev et al, 2010b).
These mice develop progressive motor failure at 8 months of age leading to paralysis and death [ 62].
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Nonetheless, the transgenic mice developed progressive hindlimb paralysis and demyelination.
Stenotic kidneys of db/db mice developed progressive interstitial fibrosis, tubular atrophy, and interstitial inflammation.
Zheng et al. reported that female mice developed progressive glomerulosclerosis after menopause [ 31].
These mice developed progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG [ 9].
These mice developed progressive skeletal degeneration that strongly resembles human OA.
More suggestions(15)
mice develop myasthenic
mice develop early-onset
mice suffer progressive
mice develop high
mice develop local
mice develop glaucoma-like
mice develop severe
mice develop renal
mice have progressive
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mice develop lethal
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