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NF-κB p50-deficient mice develop glaucoma-like optic neuropathy [29].
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Ocular enlargement, occlusion of the trabecular meshwork, and development of synechias are often associated with increased intraocular pressure and the question of whether PPCD1 mice develop glaucoma is currently under investigation.
DBA/2J mice develop glaucoma as a result of a disease of the iris that leads to an elevation in IOP.
Our previous study showed that GLAST-deficient mice develop NTG-like phenotypes, which suggests that GLAST dysfunction may underlie or contribute to RGC loss in glaucoma patients.
16 BAFF-transgenic mice develop Sjögren-like symptoms.
Hence, it is possible that Tfap2e−/− mice develop OA-like symptoms with advanced age.
Interestingly, after multiple pregnancies, the Nf2 defective mice develop myoepithelioma-like breast tumors at high frequency.
Mecp2 Stop mutant female mice develop Rett-like symptoms late in life (>6 months).
These mice develop a lupus-like syndrome with autoantibodies and CLE-like skin lesions.
After ear tagging, Ro52/TRIM21-/- Ro52/TRIM21-/-n SLE-like phenotype [ 19].
After local damage induction by ear tagging, Ro52/TRIM21−/− mice develop a lupus-like phenotype.
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