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Following scarification with VV, both transgenic and wild-type mice develop local pox.
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After 14-23 weeks, all mice developed local tumors at the site of injection.
After cutaneous sensitization and challenge of the mice by painting FITC on one ear, wild-type mice developed a local inflammatory response that was measured as an increase of ear thickness with a peak around 24 h after challenge (Fig. 2A).
Three mice (33%) developed metachronous liver and lung metastases, five mice (56%) developed peritoneal- and lymph node metastases and six mice (67%) developed local regrowths.
Sclerostin blockade was initiated when mice had already developed local and systemic bone loss to permit the assessment for bone repair.
After local damage induction by ear tagging, Ro52/TRIM21−/− mice develop a lupus-like phenotype.
In vivo, human TNF transgenic mice develop severe arthritis with chronic synovial inflammation, cartilage destruction, and systemic and local bone loss [ 40].
Human tumour necrosis factor transgenic mice (hTNFtg mice) developing inflammatory arthritis and local and bone loss were administered either vehicle, anti-TNF antibody, Scl-Ab, or a combination of both agents.
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We're always developing local solutions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com