Sentence examples for mediate destruction of from inspiring English sources

Besides TNF-α, we have also shown that neutrophil elastase, as well as PAF, mediate destruction of L. (L).

In a mouse model, adoptively transferred Th17 polarized cells were able to mediate destruction of advanced B16 melanoma and induce vitiligo, but this therapeutic effect was critically dependent on IFN-γ production, whereas IL-17A and IL-23 depletion had little impact [51].

Additionally, IL-12 secretion may mediate destruction of antigen-negative tumor cells through bystander immune responses.

Similar to RA, the pathogenesis of CIA is a multistep process driven by major histocompatibility complex restricted T cells that mediate destruction of the joint characterized by fibrin deposition, synovial inflammation, periosteal bone formation, pannus formation and ankylosis of one or more articular joints [ 6, 8].

PLP139 151 reactive T cells primed in the lymph nodes draining the site of immunization differentiate into Th1/Th17 effector cells and traffic to the CNS where they are reactivated by CNS-resident APCs to induce local inflammation and the recruitment of macrophages, monocytes, and neutrophils that nonspecifically mediate destruction of the myelin sheaths.

b, Immune-mediated destruction of autoreactive cells (graft-versus-autoimmune host T and B cells).

We found that Methyl-β-cyclodextrin (MCD) mediated destruction of lipid raft domains inhibited BLP-triggered expression of the hBD-2 gene in HLA-DR+/TLR2+ cells (Figure 3C).

We explored the role of peroxisomes with various mutants lacking peroxisome biogenesis or autophagy pathways mediating destruction of peroxisomes.

By targeting these critical signaling pathways, resveratrol decreased AGEs-stimulated expression and activity of MMP-13 and prevented AGEs-mediated destruction of collagen II.

CTX-I is a measurement of Cathepsin K-mediated destruction of type I collagen and is the standard measure for bone resorption [ 7].

AAV vectors have been shown to have distinct advantages with regard to CTL-mediated destruction of transduced cells relative to adenovirus vectors.