Sentence examples for binding and transactivation of from inspiring English sources

This can occur as a result of covalent modifications that disrupt the C-terminal negative regulatory domains of p53 tetramers, leading to conformational changes compatible with DNA binding and transactivation of p53-responsive genes [45].

The subsequent elevation in Nrf2 protein levels leads to Nrf2 nuclear accumulation, increased ARE-Nrf2 binding, and transactivation of its downstream genes [15], [16], [17], [18], [19], [20], [21].

Myc binding and transactivation of snoRNA host genes in vertebrates.

Subsequent to the binding and transactivation of Abl by Crk, Crk Y221 is itself an excellent substrate for Abl, and binding of Crk to Abl reflects a potent downmodulatory signal [ 108].

In contrast, HIF-2α is a catabolic regulator of OA cartilage destruction (26), and the binding and transactivation of MMP13 by HIF-2α were shown to be inhibited by methylation of a specific CpG site in the proximal promoter (15).

For example, the HZF protein was shown to associate with p53 to allow binding and transactivation of the p21 and 14-3-3σ 14-3-3σ 14-3-3σ blocking binding to the BAX locus (Das et al, 2007).

Conversely, the p53-binding protein ASPP2 was shown to increase binding to and transactivation of BAX, but not p21 (Samuels-Lev et al, 2001).

Seven of the PU.1 mutations in AML patients affected the DNA-binding domain, and we demonstrated that those PU.1 mutations were deficient in DNA binding to and transactivation of the macrophage colony-stimulating factor receptor promoter, a direct PU.1 target gene.

Promoter activity and ChIP analysis indicated that AP-2 α induces p27kip1 protein levels by direct binding to and transactivation of its promoter.

WT1 and p53 co-immunoprecipitated in adenovirus E1A-immortalized baby rat kidney cells, and this association resulted in stabilization and increased levels of p53 with enhanced binding to and transactivation of a promoter containing the p53 RGC target sequence.

This, in turn, results in the activation of protein kinase A, phosphorylation of the cAMP-response element-binding protein, and transactivation of target gene expression [ 20].