The linkage of improved TRAIL activity with binding and activation of CD40 has two considerable advantages compared with non-targeted TRAIL variants.
We next investigated the potential interaction sites that enable ubiquitinPhospho-Ser65 binding and activation of Parkin E3 ligase activity.
Following ligand binding and activation of EGFR by autophosphorylation, Clb directly binds to activated EGFR via the TKB domain [ 23- 25].
Binding to GTP induces a conformational change in a Rho protein, which allows binding and activation of downstream signaling molecules [ 19].
TrkA reduces and p75NTR activates β secretase cleavage of the APP, which requires NGF binding and activation of the second messenger ceramide [ 28].
RA's actions are mediated by its binding and activation of specific RA receptors that are members of a family of ligand-activated transcriptional regulators (Mark et al., 2006).
MK-2206 binds to the pleckstrin-homology (PH) domain of Akt and therebindshibito PDK1 binding and actheation of Akt.
(C) Cartoon summarizing capsaicin binding and activation of TRPV1.
Specifically, the elevated ROS in IKKβ-null cells induce c-Jun binding and activation of the Tgfβ promoter.
We have investigated the role of two polymorphic sites (R190W and N192K) on the binding and activation of the formyl peptide receptor (FPR) by viral and formyl peptides.
Like most GPCRs, V2R's third intracellular loop (V2R-i3) is involved in the binding and activation of its major effector, the GαS protein.
