Sentence examples for binding and function of from inspiring English sources
Mutation of the alanine at the 809 position of rat mGlu5 to a valine (A809V/rmGlu5) reduces the binding and function of MPEP and inhibits functional responses to PAMs that act at the MPEP site, such as VU-29 (8, 14, 20) but has no effect on responses to CPPHA (14).
We propose a new model for the genome-wide binding and function of Kaiso whereby Kaiso binds to unmethylated regulatory regions and contributes to the active state of target promoters.
The compounds are designed as ligands to study binding and function of the α7-nAChR.
The binding and function of VCP746 at the A2BAR was rigorously characterised in a heterologous expression system, in addition to examination of its anti-fibrotic signalling in cardiac- and renal-derived cells.
Certain MSP-1-specific monoclonal antibodies (mAbs) react with conformational epitopes contained within the two epidermal growth factor domains that comprise MSP-119, and are classified as either inhibitory (inhibit processing of MSP-142 and erythrocyte invasion), blocking (block the binding and function of the inhibitory mAb), or neutral (neither inhibitory nor blocking).
As noted above, further insight into the binding and function of group IIA sPLA2 awaits future investigation.
Here we have used a comparative evolutionary approach in four species of Drosophila to study the binding and functions of two group B Sox proteins, a family of TFs that is both deeply conserved throughout animal evolution and displays evidence of functional redundancy.
The T-DNA insert in this line is within the region encoding the S1 RNA binding domain, which would be expected to eliminate the binding ability and function of this protein.
These differences in binding, expression and function of classical HLA complexes on the one hand and β2 microglobulin-independent forms on the other could be involved in the pathogenesis of SpA.
The dehydrated crystal structure of apo Mtb-BirA reported here provides the active structure of the disordered loops involved in the ligand-binding and functioning of BirA.
The effects of point mutations on thermodynamic parameters of binding and function can reveal energetic coupling of neighbouring (and distant) amino acid residues in activation.
