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The results confirmed the minor groove binding and selectivity of both polyamides for the cognate sequence 5′-ACGCGT-3′.
The binding ability was also evaluated, and the findings demonstrated high glucose binding and selectivity of imprinted particles compared to NIPs.
I have built a structural model of the chemokine receptor CCR5 and used it to explain the binding and selectivity of the antagonist TAK779.
The results gave evidence for the minor groove binding and selectivity of polyamide 5 for the cognate sequence 5′-ACGCGT-3′, and with strong affinity (Keq = 2.3 × 107 M−107
With support of docking computations we propose a hypothesis on the effect of the ligand structure and pH dependency of the binding and selectivity of amino alcohols to Cel7A.
In order to guide experimental design, a kinetic model was built to explore how the affinity and valency of dual-ligand liposomes affect the binding and selectivity of delivery to cells with various receptor expression.
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Since library construction was based on peptides previously selected for binding and selectivity to specific RNAs, the number of target-specific clones increased dramatically following in vitro maturation.
1g, h Given the comparable magnitude of binding and selectivity for H2PO4 – by the similarly structured receptors 1 and 2, it is likely they coordinate via similar conformations.
These pockets can be used to further improve the binding affinity and selectivity of the currently available AKR1C3 inhibitors.
The diol binding capacity and selectivity of the phenylboronic acid remain unchanged after anchoring to polymer nanoparticles (16 nm diameter, 0.22 mmol/g).
It resulted to increasing of the binding affinity and selectivity of the functionalized derivatives specifically to (TRP V1 ∈ 1.36 1.72 and ∈2.50 3.16 higher than 1 3.
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binding and reduction of
binding and presentation of
binding and formation of
binding and stimulation of
binding and induction of
binding and activation of
binding and maintenance of
binding and insertion of
binding and transport of
binding and function of
binding and phosphorylation of
binding and dissociation of
binding and interaction of
binding and stability of
binding and internalization of
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