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The binding and uptake of functionalized liposomes were reduced to levels comparable to IgG functionalized liposomes upon a 10-fold reduction in liposome membrane diffusivity.
IgM also promotes the binding and uptake of microparticle-coated beads.
However, running mechanism studies showed a specific binding and uptake of apolipoprotein-modified HSA nanoparticles on endothelial cells.
That study nicely support that the CROPs are not solely responsible for binding and uptake of at least TcdA.
Both of these media showed similar IgM-mediated binding and uptake of small particles (data not shown).
This analysis revealed that IgG effectively directs macrophage binding and uptake of both small and large particles.
Physical properties such as charge and pH have been shown to influence binding and uptake of ligands by antigen presenting cells (APC) [7].
Conversely, gate B (Fig. 6C) best illustrates the concentration dependent effect of IgM on enhancing the binding and uptake of small particles by macrophages.
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Cell-surface proteins are also known to play an essential role in providing nutrition to the cell through binding, degradation and uptake of carbon and nitrogen substrates.
The chapter also discusses the expanding field of ferri-siderophore chemistry and its application to the design of synthetic iron chelators for the study of siderophore binding and uptake in mimics of biological systems, and in therapeutic applications.
It has recently been discovered that megalin, a large multiligand endocytic receptor of the low density lipoprotein receptor family, is capable of binding and mediating uptake of the soluble form of the GPI-anchored folate receptor Folr1, providing yet another pathway for the cellular internalization of folate [ 9].
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binding and formation of
binding and transportation of
binding and function of
binding and induction of
binding and stability of
binding and stimulation of
binding and presentation of
binding and reduction of
binding and activation of
binding and internalization of
binding and insertion of
binding and transport of
binding and maintenance of
binding and dissociation of
binding and phosphorylation of
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