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The use of AAD as a cross-linker allows for selective binding and recognition of arginine among other amino acids.
The windfall of this, and other more recent structural information, has elucidated some generalizations for TCR binding and recognition of pMHC.
Here, we show the binding and recognition of dissimilar DNA sequences by an 18 amino-acid peptide (α1E2), which corresponds to the DNA-recognition helix, α-helix-1.
These mechanistic investigations involve research focused on understanding interactions of platinum agents with DNA since DNA binding and recognition of DNA modified by these metallodrugs are the important processes responsible for their anticancer properties.
To identify new receptors involved in binding and recognition of mycobacteria, a retroviral cDNA expression library, generated from RAW264.7 macrophages [24], was stably expressed in NIH3T3 cells and visually screened by fluorescent microscopy for binding of live Mycobacterium bovis bacillus Calmette-Guérin expressing Green Fluorescent Protein (BCG-GFP).
We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4.
Similar(47)
The PWWP, HMG, and PHD domains are responsible for nuclear localization, DNA-binding, and recognition of histone marks [ 8– 11].
Similarity in ligand binding sites can indicate common binding modes and recognition of similar molecules, allowing potential inference of function for an uncharacterised protein or providing additional evidence of common function where sequence or fold similarity is already known.
Thus, Y271W directly probed the local solvation (hydration) dynamics and the changes upon binding DNA and recognition of the incoming nucleotide at the active site.
We recently proposed that the intrinsically disordered structure of TAX allows a wide variety of conformational changes enabling binding diversity and recognition of differently shaped protein partners.
The beta sheets line the binding pocket, and recognition of the 7-methylguanosine moiety is mediated by base sandwich-stacking between conserved residues W56 and W102 as well as with E103.
More suggestions(15)
binding and activation of
binding and regulation of
binding and transport of
binding and insertion of
binding and function of
binding and formation of
binding and reduction of
binding and induction of
binding and interaction of
binding and stability of
binding and folding of
binding and phosphorylation of
binding and dissociation of
binding and stimulation of
binding and retention of
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