Sentence examples for binding affinity caused by from inspiring English sources

This matching score integrates the loss of binding affinity caused by both nucleotide and structure deviances from reference motif.

(B ) Conformational changes caused by the phosphorylation of Ft and Ds could provide an explanation for the differences in binding affinity caused by apparently similar phosphorylation events.

This suggests that the loss of PG immunoreactivity from the intercalated disk, as seen in our ARVC patients, is a result of a more complex mechanism than just a simple change in binding affinity caused by the missense mutation.

Analytical size-exclusion chromatography revealed no degradation of the monomeric protein at this time point, suggesting that the initial decrease in immunoreactivity was due to reduced binding affinity caused by exposure of the scFv to the elevated temperature.

In both the wild-type and the D12A/D66A backgrounds, the ∼5-fold decrease in dNTP binding affinity caused by the Y254V mutation is largely due to an increase in the dNTP dissociation rate (Table 1).

It considers degenerative features of binding motifs by calculating the differences on the binding affinity caused by the candidate variants and integrates potential phenotypic effects of various transcription factors.

Therefore, changes in binding affinities caused by temperature-induced structural changes are expected to be negligible.

Ffh [ 25], FtsY [ 26] and Irga6 [ 11] share nearly identical low nucleotide-binding affinities, caused by a high substrate dissociation rate.

There are suggestions indicating that C to T change increases the expression by lowering the binding affinity, causing corepressor to release from the DNA strand.

Thus, the reduction in affinity caused by conformational variability of the protein target can be partially or wholly offset by compensatory binding to the up conformation.

We demonstrated the potential of RNAMotifModeler by an application to predicting binding specificities of SRSF1 proteins and obtained a reference motif of 'AGAAGAAG' with a parameter matrix including retained binding affinity ratios caused by sequence degeneracy, as well as probabilities for nucleotides being unpaired.