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This dramatic loss in activity may be due to an alteration of the binding mode caused by the biaryl unit or the physiochemical properties of the molecule.
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Precluding cis-binding mode caused a reduction of about 25% in the maximal D-CaM fluorescence, as revealed by comparing ABCD and ABCD# (Fig. 5A).
This binding mode difference is caused by the P1G mutation.
This decreased binding is caused by aPL that outcompete annexin A5 binding, causing a pro-thrombotic state.
This may occur by drastically changing the binding mode, for instance, by causing the peptide to rotate.
Typical failure modes are caused by rotator-cuff forces (Gardner et al. 2007).
These different binding modes in nNOS and eNOS, caused by the Tyr residue mobility, have proven to be the basis for the sharp differences in inhibitor potency (Table 1).
Very little mode coupling effect caused by the off-diagonal terms was found.
Finite modes have only other finite modes for causes, but being caused by other finite modes is a way of being determined by God's power, since finite modes just are limited expressions of God's power (Ip36d).
This change may result from the different binding orientation of the acceptor caused by substitutions in the acceptor-binding site.
We also noticed another binding mode indicated by "ii" with −4.35 kcal/mol in Fig. 4c, an intermediate state between the off-site binding mode "i" and the interrupted on-site binding mode "iii".
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