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As a result of impairment of the GSTP1 substrate binding capacity caused by the underlying A → G substitution, patients homozygous for the GSTP1-105 variantvariant may accumulate more drug compared to patients possessing one or two wild-type alleles (Watson et al, 1998).
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Moreover, several mutations within the cyclophilin A binding loop, such as H219 and M228, have been shown to compensate to some extent for the reduced viral replicative capacity caused by T242N [28], [28].
The decreased slope is a marker of decreased aerobic exercise capacity caused by decreased oxygen transport.
These drastic changes in measured TIF likely occur from slight changes in the binding pocket caused by different co-binding peptides P1, P2, and P3.
This decreased binding is caused by aPL that outcompete annexin A5 binding, causing a pro-thrombotic state.
The cause of this different water binding capacity was investigated and was caused by a different degree of crystallinity.
This approach revealed the cause of binding capacity decay by determining the amount of adsorbed protein on the beads and the conformation of the immobilised protein ligand.
This binding mode difference is caused by the P1G mutation.
These results also suggest that the observed differences between the groups were not caused by different binding capacities to the GAD65Ab epitope defined by b96.11.
This change may result from the different binding orientation of the acceptor caused by substitutions in the acceptor-binding site.
Serum transferrin saturation was calculated by dividing serum iron by total iron binding capacity determined by the calorimetric method.
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CEO of Professional Science Editing for Scientists @ prosciediting.com