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We found that BALB/c mice represent a more susceptible mouse strain compared to C57BL/6 mice after intranasal S. aureus Newman challenge.
Previously, we reported that the expression levels of IL-21 and its receptor were increased in the autoimmune prone NOD mouse strain compared to mice that contain the corresponding protective interval from C57BL/6 mice.
Figure 1 shows the survival curves of each single or double transgenic mouse strain compared to the wild type (WT) controls.
Indeed, it has been demonstrated that DBA/1 MSCs formed osteocytes very potently but differentiation into adipocytes was much more difficult in this mouse strain compared with other strains [ 30].
Cardiac pathology and adaptation to HFD-induced obesity in the MRL mouse strain compared to the HFD C57Bl/6 mice were thoroughly analyzed with echocardiography, histology, qPCR, electron microscopy and immunoblots.
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The PLS-DA scores plot of the first two partial least squares (PLS) components, PLS1 and PLS2, (Figure 4C) showed improved separation of the three mouse strains compared to the PCA.
Task 5, the first double transfer task where the animal must associate reward with a new set of odorants, was significantly more difficult for all three mouse strains compared to tasks 2, 4, 6, and 7, which represent positive and negative transfer tasks, where only the rewarded or unrewarded odorants are changed respectively (Wilcoxon, p<0.05).
Also LV function was equally impaired in both hypercholesterolemic mouse strains compared to age- and diet-matched C57Bl/6J mice.
The red (pro-aggregant TauRDΔ) and green (anti-aggregant TauRDΔPP) bars indicate the alteration of the synaptic levels within these mouse strains compared to WT (gray) and TKO (blue) mice.
Although such an approach has the potential to improve the mapping accuracy of RNA-seq reads for non-B6 mouse strains, compared with using the B6 reference, it is severely limited by and dependent on the accuracy and coverage of within-strain genomic variations.
In order to identify host genes with important effects on influenza pathogenesis, we performed a quantitative trait locus analysis on genetically diverse mouse strains comparing the early inflammatory response after H5N1 virus infection.
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mouse lineage compared
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Justyna Jupowicz-Kozak
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