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The chimeric JEVpr/DENV2 displayed significantly reduced infectivity, plaque size, and mouse neurovirulence compared to RecDENV2 (Fig. 2a c).
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The mouse neurovirulence test showed a number of essential advantages over the monkey test.
All of the variant viruses were attenuated for mouse neurovirulence (≥13-fold).
Immunoblotting for OPN from mouse bone extracts showed altered OPN processing in PC5/6-knockout mice compared to wildtype mice.
(F and G) DNA damage is increased in Hdac6 knockout (KO) mice compared with WT mice.
The FC/CB ratios were clearly elevated for APP23 mice compared to WT mice (Figure 5b).
Our results revealed a lower mortality in catalase mice compared with FVB mice after LPS challenge.
The SUVs for [18F]FDG-6-P injected mice (Figure 5b) demonstrated a lower background signal in uninfected mice compared to infected mice and compared with [18F]FDG control mice.
mice were compared with WT mice.
Both treatments significantly prolonged the survival of the treated mice compared with the control mice.
Ipsilateral projections are reduced dramatically in Zic2 knock-down mice compared with control and heterozygous mice.
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