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In spontaneous dwarf rats, increased resistance to hyperoxic stress was associated with reduced signs of DNA damage in multiple organs including the lung and contributed to an extended life span of this rat strain compared to their wild-type controls [19].
Coevolutionary gene clusters were identified using transcripts that showed nonsynonymous coding (NSC) mutations in at least one rat strain compared to the reference BN genome.
Identification of Coevolutionary Gene Clusters Coevolutionary gene clusters were identified using transcripts that showed nonsynonymous coding (NSC) mutations in at least one rat strain compared to the reference BN genome.
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The responses of two different inbred rat strains were compared: the Dark Aguoti (DA), susceptible to chronic inflammatory disorders, and the Brown Norwegian (BN), susceptible to atopic allergic inflammation.
While we were documenting the sequence variability of the rat CD94L class Ib molecule RT-BM1 among rat strains, we compared the rat class Ia and CD94L sequences to those of mouse and human [ 28].
The purpose of this study was to define, both qualitatively and quantitatively, the manner in which the mammary glands of susceptible ACI and resistant BN rats respond to E2. Dramatic differences in multiple cellular and molecular responses to E2 were observed when these two inbred rat strains were compared.
In order to determine the genomic distributions of these clusters we divided the genome in segments containing 20.000 SNVs, in each window the genotypes of the different rat strains were compared to the average genotype profile of each of the 9 groups.
Instead of comparing two rat strains knowing that each have 'decreased systemic arterial systolic blood pressure' as annotated with MP, quantitative annotations allow the database user to know how much lower the 'mean arterial blood pressure' is in one strain compared with a different strain or to the same strain under different conditions.
In addition, the gene expression profiles for glomerular cytokines were significantly different in the bicongenic rat strain affected by NTN compared with the parental LEW strain.
The WKY rat strain appears to show differences compared to the SD strain in the same TLRs as the MS versus NS rats but also in several other TLRs, namely TLR7, 8, 9, 10.
Comparing vesicles isolated from Wistar and TR− rats, both rat strains showed comparable uptake characteristics for TC (Fig. 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com