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PCR‐amplified DNA fragments showed a sustained luciferase activity in mouse liver compared with pLuc, indicating that they are effective in achieving a prolonged expression.
It is also possible that, similar to what has been observed in the eye of mice [64], the RB family members p107 and p130 have a stronger overlapping role in the mouse liver compared to the human liver.
In vivo tissue distribution assay showed that IFN-CSP was able to accumulate in mouse liver compared to native IFN α2b (Fig. 10).
As show in Fig. 1C, HBV DNA levels were more than 2-fold higher in mouse liver compared to their own input vector level.
The purified IFN-CSP was able to accumulate in mouse liver compared to native IFN α2b and reduce serum HBsAg, HBV-DNA and liver HBV core protein in HBV-transgenic mice.
Notably, levels of Dicer mRNA were significantly reduced in old WT mouse liver compared to tissue from young mice and in late passage MEFs compared to early passage (Supplemental Figure 5B).
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The expression of FGF21 was increased about 6 fold in the LKB+/− haploinsufficient livers, and strikingly more than 30 fold in the compound p53+/−LKB1+/− mouse livers compared to the wildtype counterparts.
Western blot analysis showed that the ∼42 kDa cleavage product that corresponds to activated caspase-12 was significantly diminished in HDAd-TFEB injected mouse livers compared to control livers (Fig 10D).
Of the ten miRNAs downregulated in Ercc1−/− MEFs, eight (miR-449a, miR-455*, miR-128, miR-497, miR-543, miR-450b-3p miR-450b-3p miR-450b-3pere also down-regulated in both the progeroid and old WT mouse livers compared to the WT young (20 week) control mouse livers.
Furthermore, a significant decline of p62 protein level was observed in CMZ/ethanol group mice liver compared with that of the ethanol group mice.
PM1 also improved oral glucose tolerance significantly (p < 0.05) with mean percentage reduction of 48.0% in glucose excursion (AUC0 120 min) and significantly (p < 0.05) enhanced the endogenous antioxidant status in mice liver compared to diabetic control.
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mouse serum compared
mouse neurovirulence compared
mouse condition compared
mouse hypothalamus compared
mouse brain compared
mouse model compared
mouse liver exposed
mouse cerebellum compared
mouse liver harvested
mouse peptide compared
mouse strain compared
mouse genome compared
mouse muscle compared
mouse liver relative
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