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We identified 375 genes that showed differential expression in rods from 5 and 12 month old mouse retina compared to that of 1.5 month old retina.
Additionally, at least two, TRIM27 and TRIM23, demonstrate altered expression in Ataxin-7266Q/+ Ataxin-7266Q/+omoused with wild-type litteretina.
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The results indicate an increased level of Gab1 phosphorylation in PTP1B knockout mouse retinas compared to wild type retinas.
The results indicate a reduced binding of Grb14 with the vSrc-SH2 domain in Ins2Akita mouse retinas compared to controls, suggesting that Grb14 phosphorylation is reduced in type 1 diabetic mouse retinas.
We defined a bright green area as a YO-PRO-1 positive area (Figures 3B and 3D), and quantified YO-PRO-1 positive areas on rat and mouse retinas, comparing with those on acutely isolated retinas.
In conclusion, degeneration of the RPE with subsequent photoreceptor degeneration by NaIO3 lead to longer mean fluorescence lifetimes of the retina compared to control mice, whereas during specific degeneration of the photoreceptor layer induced by MNU shorter lifetimes were measured.
The total number of calretinin-positive cells was significantly higher in the postischemic P2Y1R-KO retina compared with values found in Wt mice in both layers.
This finding mirrors that of our previous work, which showed that CBA/J mice have greater numbers of light responsive cells in the retina compared to controls [ 6].
WT OIR mice treated with MDL 72527 for 2 days showed significantly reduced apoptosis in the retina compared with vehicle-treated controls.
BAX-deficient mice were previously shown to exhibit a thicker inner nuclear layer and plexiform layer in the retina compared with wild-type controls.
Each of the other four independent assays showed an increase in oxidative stress in the Vldlr-/ retina compared to the WT control and demonstrated a decrease in oxidative stress in the retinas of Vldlr-/ mice injected with nanoceria.
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