Sentence examples for modulate vascular function from inspiring English sources

Substantial pre-clinical and some clinical data are available showing that Asian ginseng (Panax ginseng C.A. Meyer) varieties or its particular ginsenosides exert a vasodilatating effect, thus may modulate vascular function.

However, studies have not addressed the ability of neutrophils to modulate vascular function in vivo.

Apart from the metabolic effects, treatment with DPP-IV inhibitors is supposed to exert several pleiotropic activities which might modulate vascular function in T2DM [ 31, 32].

Yet, in a recent study a 6-month GLP-1 receptor agnist treatment did not modulate vascular function, despite significant improvements in body composition and glycaemic control [ 15].

Finally, through interactions with adhesion molecules they may activate endothelial signal transduction, although this is less well understood Previous experiments have addressed the idea that neutrophils may modulate vascular function by examining vascular tone in isolated aortic rings in vitro.

The results of this study suggest an important role for endothelial TP receptors in modulating vascular function.

Although diabetes-associated alterations, like enhanced glycoxidative stress and insulin deficiency, directly affect endothelial cell (EC) survival and function, recruited cells have a critical role in further modulating vascular function by secretion of cytokines, proteases and radicals, like nitric oxide (NO) or superoxide (O2−*).

To investigate the mechanism of modulating vascular function in ApoE-KO mice treated with OCN, total and phosphorylated PI3K, Akt and eNOS expression were detected.

Adiponectin is present in the circulation as three distinct oligomeric complexes [ 35] and it has been described as having a key role in modulating vascular function [ 16].

Since therapeutic strategies targeting the central nervous system are limited, modulating vascular function presents an exciting opportunity to lessen the burden of disease in these patients.

In this respect studies by Secchiero's group [ 58, 59] and other investigators [ 60] have suggested that TRAIL plays an important role in modulating vascular function and might have prognostic value in diabetic patients affected by cardiovascular complications [ 61– 63].