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The Angptl4 gene product is thought to modulate vascular activity and tumor cell motility and invasiveness, which implies its significance for tumor progression and metastasis [44-46] [44-46]
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Apart from the metabolic effects, treatment with DPP-IV inhibitors is supposed to exert several pleiotropic activities which might modulate vascular function in T2DM [ 31, 32].
These data provide important targets for future studies to modulate vascular remodeling.
The proximal portions of the large intracranial arteries are innervated by noradrenaline-containing sympathetic afferents, which modulate vascular tone.
Furthermore, proximal parts of the intracranial vessels are strongly innervated by sympathetic afferents, which modulate vascular tone.
We next examined the expression of factors that modulate vascular stability.
Moreover, monocytes/macrophages also modulate vascular calcification in vitro [ 27].
However, studies have not addressed the ability of neutrophils to modulate vascular function in vivo.
αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion.
The metabolic and hemodynamic profile of diabetes, including comorbidities such as hypertension, hyperinsulinemia, and obesity, modulates vascular health and neuronal activity through multiple overlapping mechanisms.
We used in vitro approaches, ex-vivo rat aortic rings and the EA.hy926 endothelial cell line in culture to address how CORM-401 releases CO and whether the compound modulates vascular tone and pro-angiogenic activities, respectively.
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