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Thus, they are of physiological and clinical relevance for their ability to modulate inhibitory function in the CNS.
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For instance, NA action on β-ADR modulates inhibitory synaptic function.
Therefore, Shh may modulate the activating and inhibitory function of Gli3, so that, in the absence of Shh, Gli3 will be processed to the repressor form.
In turn changes at this binding site (with inhibitory function) would strongly modulate transmitter release in DA systems.
Therefore, a feedback-regulatory loop also exists in the p73-Mdm2 netwhich which relies only on the inhibitory function of Mdm2 to block p73-transcriptional activity and inhibit apoptosis, rather than modulating its steady-state levels.
Rights & permissionsfor article Human disease mutations highlight the inhibitory function of TIM-3.
The SNX5/6 IncE interaction is required for cellular localization of IncE and its inhibitory function.
These results suggest that DA may modulate inhibitory synaptic transmission in CeA through D(1) receptor activation primarily by a presynaptic mechanism.
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are neurosteroids that modulate inhibitory GABA receptors and excitatory NMDA receptors, producing complex neuronal effects.
Because these phenotypes cannot be explained by the established inhibitory functions, additional mechanisms by which HCMV modulates the class I pathway of antigen presentation are likely to exist.
The inhibitory functions are not present at birth; it takes many years for the necessary biological processes to hone a prefrontal cortex into an effective, efficient executive.
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