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Statins have anti-inflammatory effects [28,39] and may modulate endothelial function modifying responses to open AAA surgery.
Toxins can also modulate the immune response by influencing endothelial biology, and can modulate endothelial function by influencing the response of leukocytes.
Microparticles have procoagulant properties, modulate endothelial function, and play a role in inflammatory processes [ 16].
We also measured blood pressure, glucose tolerance and lipid metabolism, which are known to modulate endothelial function.
Local expression of FABP4 in endothelium and/or circulating FABP4 might directly modulate endothelial function and blood pressure.
Thus, the expression patterns of extracellular miRNAs that modulate endothelial function and inflammatory signaling may provide key insights into mechanisms that contribute to endothelial activation and injury in the setting of severe sepsis.
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Other interventions are currently in the pipeline, most of these aimed at modulating endothelial function.
ROS are essential for physiological functions such as gene expression, cellular growth, infection defense, and modulating endothelial function [4 6].
Reactive oxygen species (ROS) are essential for physiological functions including gene expression, cellular growth, infection defense, and modulating endothelial function.
These results suggest that OCN plays an important role in modulating endothelial function in vivo.
HCQ was totally ineffective in modulating endothelial function in Ctrl animals (Additional file 1).
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