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In preliminary experiments we have observed that TLQP-21 can modulate macrophage function.
However, exosomes containing mycobacterial components may also modulate macrophage function to promote mycobacterial survival.
Macrophage expression of adipokine receptors for both leptin and adiponectin suggests that adipocytes may also modulate macrophage function [6] [7].
Our data indicate that apoptotic cells modulate macrophage function and result in Treg generation/increase.
It has been demonstrated that T lymphocytes modulate macrophage function in vivo and in vitro.
It is essential to establish the underlying mechanisms of age-related macrophage impairment, in order to aid the design of treatments to modulate macrophage function.
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In fact, extracellular vesicles isolated from the yeast pathogen C. neoformans were recently reported to modulate macrophage functions [42].
Since accumulating evidence [13], [14], [15], [16] has demonstrated that adiponectin may modulate macrophage functions, and since macrophages are involved in regulating tumor growth and progression, we decided to examine the degree of macrophage infiltration by immunohistochemical staining with the anti-F4/80 antibody, which recognizes a specific macrophage antigen.
MIP-1β is known to modulate macrophage functions, is an important mediator of chronic inflammatory processes [ 19, 20], and is a potent macrophage, lymphocyte and specifically activated CD4+ lymphocyte chemo-attractant [ 20].
A common feature of plant polysaccharides that modulate macrophage functions may be higher molecular weight, as we found previously that immunomodulatory activity positively correlated with increased molecular weight of various plant polysaccharides [ 23- 25, 36].
Horton and coworkers [ 78] reported that small-molecular-weight fragments of hyaluronic acid would serve to modulate macrophage functions through nuclear factor-κB signalling synergistically with interferon-γ [ 78].
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