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Our results thus suggest that epigenetic modifications constitute a primary response to elevated sleep pressure showing the potential to integrate different brain processes, and to modulate synaptic function notably by affecting the expression of synaptic elements.
Furthermore, several different molecules can modulate synaptic function at a single neuron [27].
Many different pathways have been described, all of which modulate synaptic function.
This could, as discussed earlier, modulate synaptic function and additionally impair mitochondrial function.
Both acute and chronic ethanol exposure can modulate synaptic function and plasticity in the dorsal striatum and the BNST.
Consistently, we have recently shown that HSPG co-receptors acting as potent regulators of trans-synaptic signaling also strongly modulate synaptic function (Dani et al., 2012).
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SPARC has also been proposed to modulate synaptic functions and to be involved in higher cortical functions in adult mammalian brains [ 39], making this a candidate for depth-preference behaviour [ 1].
Furthermore, a recent study indicates a novel mechanism by which Zn2+ can modulate synaptic functions as the cation is able to activate mitogen-activated protein kinase (MAPK) and CaMKII by acting on a putative Zn2+-sensing receptor (ZnR).
The set of upregulated genes nonetheless shows some nervous system specificity, including the upregulation of RNAs modulating synaptic function, including Homer1, Arc, Syt4, and Pnoc.
To further understand the molecular mechanisms by which Stau2 modulates synaptic function in neurons, it is important to identify and characterize protein co-factors that regulate the fate of Stau2-containing mRNPs.
This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits.
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modulate pDC function
modulate nociceptive function
modulate hippocampal function
modulate ERα function
modulate immune function
modulate synaptic activity
modulate synaptic transmission
modulate synaptic action
modulate leukocyte function
modulate inhibitory function
modulate endothelial function
modulate vascular function
modulate macrophage function
modulate mitochondrial function
modulate synaptic network
modulate neural function
modulate synaptic strength
modulate synaptic output
modulate neuronal function
modulate biological function
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