Synaptic plasticity, the ability to adapt to stimuli, tested in the form of paired pulse (PP) depression and facilitation measure the influence of local circuit neurons to modulate that synaptic output [Figure 5 (Gilbert and Sui 2008)].
If select mushroom body circuits rescue dunce1 attention defects, then silencing synaptic output from these structures should modulate brain activity correlates of attention.
It can modulate synaptic plasticity, neurogenesis, neural growth and differentiation [3].
Similarly, neuromodulators also can modulate synaptic dynamics, in a way that differs across different cell types [29 31].
It is convenient to think of these processes in terms of local feedback mechanisms that modulate synaptic currents.
Together, these results suggest that GluR6 Q/R site RNA editing may modulate synaptic plasticity and seizure vulnerability.
At the other end of the photoreceptor, at its synaptic output terminal, a similar gradation exists across these organisms, from a simple synaptic density in hagfish photoreceptors to a very specialized synaptic ribbon structure in jawed vertebrates.
The different putative sites of in- and outputs to peptidergic neurons in the VNC are summarized in Table 3. Peptides released from varicosities of leucokinin, CCAP, HUG-, EH and corazonin neurites along the DM tract may modulate synaptic transmission around the DM tracts, or might represent direct input signals to peptidergic neurons.
ASIC1 is the most abundant of all the ASICs and is likely to modulate synaptic transmission.
Morphine has also been shown to modulate synaptic plasticity at hippocampal glutamatergic synapses [58].
