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The sulfite oxidase encoded by shopper acts in ensheathing glial cells to modulate neuronal function via the glutamate glutamine cycle (Fig. 8).
Transcranial direct current stimulation (tDCS) is investigated to modulate neuronal function by applying a fixed low-intensity direct current to scalp.
Microglia play critical roles in tissue homeostasis and can also modulate neuronal function and synaptic connectivity.
It is reported that in central nervous system, glial cells release MVs, which modulate neuronal function in normal condition.
Similarly, alterations in DAG and glycerophospholipid metabolism may also modulate neuronal function in the PD VC [66].
This study has also shown the presence of TNFR2-expressing infiltrating macrophages, providing a second pathway by which TNF can modulate neuronal function in inflammatory as well as neuropathic conditions (see Fig. 6).
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Furthermore, the finding that heat-killed Lactobacillus brevis SBC8803 can modulate intestinal vagal nerve activity and autonomic neurotransmission mediated by HT-3 receptorsuggestsesthathat non-viable bacterial components may also have potential in modulating neuronal function.
Welch et al. [25] proposed that estrogen modulates neuronal function resulting in a mismatch between its gene regulation and membrane effects in MM patients.
As a tool for modulating neuronal function, US has been studied and considered across a range of uses from thermal ablation of nervous tissues to its ability to produce sensory perceptions [6], [9], [10].
Further complexity is added to the CB2 receptor pharmacology with the recent finding that their intracellular activation modulates neuronal function.
Similarly, other mast cell degranulation products such as tryptase and histamine are capable of modulating neuronal function [ 27- 32].
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