Sentence examples for notable mutation from inspiring English sources

With the exceptions of DNMT3B, which is significantly overexpressed in most cancer types studied here, and DNMT3A which is highly mutated in LAML, we do not see notable mutation rates or cancer-associated changes in expression level for DNMTs and HDACs (Additional file 2: Figure S1).

The tests revealed one notable mutation, in a gene that produces an enzyme called IDH-2.

The effects of Y49 are particularly notable; mutation of this residue abolishes binding and substantially reduces expression in the CGRP receptor (Barwell et al., 2010).

The most notable mutation is an activating KRAS (Kirsten rat sarcoma viral oncogene homolog) mutation at codon 12 (G12V), which is one of the most commonly reported mutations in ampullary carcinomas [ 13, 14].

They found 55 notable mutations related to transitional cell carcinoma, 49 of which were first found in bladder cancer.

However, our study did not detect equivalent mutations on the SRV proviral sequences of Vero JCRB0111 cells; however, other notable mutations were instead detected (Supplementary Table S5).

We observed some notable variation in germ line mutation frequencies between the 5 founders.

In this context, it is notable that mutation of Ser markedly alters activity against the MH-1 peptide.

The most notable silent-mutation-rich region of the genome was cluster GSU1095-GSU1102, which encodes a phosphate transporter and phosphate-dependent regulatory genes (Additional file 1: Table S2).

Prior to our screen, the notable meiotic mutations on the X included mei-217, mei-218, mei-9, hdm, mei-P26, mei-41, mei-38, east, Cap, Klp3A mei-352, and nod.

It is notable that a mutation of K186 was also found to abrogate the infectivity [14].