Sentence examples for prominent mutation from inspiring English sources

We established sensitive (5 10% mutant allele), reproducible and linear pyrosequencing assays for the most prominent mutation hotspots in EGFR and KRAS (Supplementary Fig. S2, S3, S4, S5, S6, S7, S8, S9, S10).

The mutation c.5266dupC 5382insCC) was a highly prominent mutation detected in 18 patients, which accounted for 51.4% of all identified alterations in BRCA1.

Reverse engineering a prominent mutation in ubiquitin-specific protease gene UBP7 in a laboratory S. cerevisiae strain effectively increased spent sulphite liquor tolerance.

12 Recent surveillance data has revealed the emergence of a prominent mutation, E47K (HA2 numbering), in the HA2 stalk region of influenza A(H1N1 pdm09 isolates.

The missense mutation R273H belongs to the most prominent mutation hot-spots in the TP53 gene and alters the target DNA sequence [ 37].

Since the deletion in the scaffold 15 is the most prominent mutation identified in Rut-C30 we wanted to study its effect more thoroughly, namely whether the deletion has an effect on hydrolytic enzyme production.

Of these genetic changes, K-Ras and p53 are the most prominent mutations associated with the urethane-induced model [ 61, 110].

While other prominent mutations have been described, such as the K285N substitution in East / Central Europe, the majority of the mutations listed in the GALT database (URL: ) are rare and likely to be family specific.

The DNA was added to individual allele-specific PCR reactions targeting seven mutations in codons 12 and 13 of KRAS, seven mutations in exons 9 and 20 of the PI3 kinase gene, the T>A transversion in exon 15 of the BRAF gene and the most prominent mutations, deletions and insertions in exons 18 21 of the EGFR gene.

Notwithstanding several prominent mutations in the DNA repair genes, no increase in the number of mutations or CNVs was observed in the L-STS and H-STS, whereas the P-STS acquired multiple chromosomal alterations during in vitro cultivation not evident in the P-Tu.

Although increased kinase activity was consistently shown for the most prominent G2019S mutation, data for other mutations are contradictory.