Sentence examples for substantial mutation from inspiring English sources
Neutral spaces for the regulatory pathway genotype are predicted to be far-reaching in terms of mutational distance, and so a pathway may undergo substantial mutation while still maintaining the same phenotype [ 16].
The substantial mutation density suggests that soybean should be an amenable subject for a high-throughput TILLING service.
The ssDNA viruses of the family Geminiviridae display substantial mutation biases that could potentially indicate the cause(s) of their high mutation rates.
Now, notice that there is substantial mutation and recombination hotspot activity in the α- and β-globin gene clusters [ 234, 236].
This strategy is not recommended because mutations can occur early or late, resulting in substantial mutation frequency fluctuation between test episodes.
We argued that the reason that these same older testes all have substantial mutation clusters for the Apert syndrome mutation is that the selection parameter for the Apert mutation is greater than for the MEN2B mutation (19).
Thus, the fitted affinities and their associated errors are not consistent with the idea that there is a substantial mutation-induced change in TOG binding affinity, and this in turn supports our claim that the conformation of the mutant cannot be very different than that of the wild-type.
Substantial mutations might have occurred during evolution resulting in a significant difference in amino acid sequence identity between these large AtACBPs and BnACBPs.
The artubulins could have also evolved by a Nitrosarchaea-specific duplication of the FtsZ gene with subsequent substantial mutations turning them FtsZ-like.
However, a clear shift from P1 to P2 usage is observed as soon as substantial mutations in the A-rich motif are combined with a point mutation in the AUUAAA hexamer.
Substantial variation in somatic mutation rates, up to 33% in normal and 60% in cancer cells, has been attributed to variation in the replication timing of DNA (Koren et al., 2012; Woo and Li, 2012).
