The A66W mutation produced conspicuous and in some respects unique effects.
Instead, we claimed that when this gene and its related genes are mutated through a random mutation process, these mutations might be conspicuous as abnormal traits.
Myelin outfoldings and redundant myelin loops, for example, are a conspicuous feature that suggests possible mutations in the myotubularin genes MTMR2 and SBF2 (Nelis et al., 2002 a; Azzedine et al., 2003).
Therefore, a conspicuous finding was a deep intronic mutation affecting DPD pre-mRNA splicing in five individuals.
Therefore, the only conspicuous difference between the two viruses is mutations localized in the 6K1/CI junction.
We identified only two sib pairs (1.4% of our families) cosegregating conspicuous RNASEL variants with prostate cancer: the nonsense mutation E265X, and a new amino-acid substitution (R400P) of unknown functional relevance.
The mutation in spo0A was the most conspicuous of all identified, so we decided to test the hypothesis that this deletion was the primary cause of the changes in phenotype we observed.
Although, mutations in LOB genes do not cause conspicuous morphological changes, expression of LOB outside of its normal domain has several morphological effects [18].
In the case of the E401K mutation, the assembly pathway was arrested, with a conspicuous retention of the mutant polypeptide complexed with prefoldin (PFD) and the cytosolic chaperonin (CCT), and a dearth of native α/β heterodimers.
This is because only mutants with conspicuous fitness effects are detected and isolated during the mutant selection process, and so the class of mutations with weakly beneficial effects (translating into slower growth) in the selection environment is undersampled.
