Sentence examples for considerable mutation from inspiring English sources

A recent HTS analysis of human parent-offspring trios suggested considerable mutation rate variation within and between human families (Conrad et al. 2011).

The development of four independent populations with considerable mutation density, together with an additional method for screening closely related targets, indicates that soybean is a suitable organism for high-throughput mutation discovery even with its extensively duplicated genome.

Another is that REs can often sustain considerable mutations, including large truncations and insertions.

It is now well documented that there is considerable variation in mutation rates (e.g. Hodgkinson and Eyre-Walker 2011), but we suspect that the implications of this for developmental bias are rarely appreciated.

It was recently shown that there is considerable variation in mutation rates within and between families, which in part can be attributed to the age of the father at the time of conception.

It is now clear that by the time a tumour is clinically apparent, it has accumulated a large number of mutations, many of these are not within gene coding sequences (the significance of which is yet to be understood) and there is considerable variation in mutations between tumours even those in the same tissue.

In reality, there is likely to be considerable variation among pleiotropic mutations in the number of traits affected (Wang et al. 2010; Runcie and Mukherjee 2013).

Inference biases were considerable for mutation-driven increases in codon bias.

Also the relative contribution of PSEN1, PSEN2, and APP mutations to early onset Alzheimer's Disease (EOAD) is the subject of considerable controversy, and mutation frequency is highly dependent upon the studied population [ 12– 15].

Analysis of four independent databases reveals that a considerable fraction of mutation in functional genes can be described by a few CMCs regardless of gene identity or population stratification in the genotyping experiment.

Despite considerable research, the mutation responsible for the polled phenotype has yet to be identified.