Sentence examples for salient mutation from inspiring English sources

Among these, we found a salient mutation in exon 7 in the DNA binding domain of TP53.

The salient mutation observed in G. g. murghi was the presence of 'T' in most of the birds (54 out of 56 i.e. 96.4%) (Fig. 4) that was present in only 33.3% of G. g. gallus, 24.4% of G. g. spadiceus and 13.1% of all the G. g. domesticus birds.

In summary, there are salient considerations for mtDNA mutation identification comparative studies between potential cancer tissue, different types and stages of tumors, as well as non-invasive collected samples and experimental controls.

Consistent with this notion, our study reveals a salient site-specific variation in the prevalence of MYD88 mutations: they were relatively uncommon in ABC DLBCLs arising in lymph nodes (17%) or gut (11%), whereas tumours arising outside these 'professional' lymphoid tissues frequently contained these mutations, either with or without a coexisting CD79B mutation.

Another salient feature of the mutations found in this study was the deletion of AGACA pentamer in exon 9 of the SMAD4 gene in one tumor tissue from a Familial Adenomatous Polyposis case [Figure 2].

The salient example is MeCP2, mutations of which are associated with a progressive neurological disorder, Rett syndrome (RTT), in humans (Amir et al, 1999) and RTT-like phenotypes in mice.

These murine models recapitulate the salient features of human NEB mutation, including severe muscle weakness, impaired force generation and histopathological changes including reduced thin filament length and the presence of nemaline rods and bodies.

We noted previously that the most salient effect of the LRRK2-G2019S mutation was to increase the sensitivity of the unmasked 1F1 and 2F1 responses and reduce the maximum amplitude of the masked response.

Seldom abnormalities in the genetic structure of some individuals in the population cause salient differences in their specifications, called mutation operator in GA.

We demonstrate that PAK7 is co-expressed with DISC1 in developing brain and further investigation of the role of the mutation in synaptic mechanisms salient to schizophrenia is warranted.

The salient point is that a high mutation rate combined with the expansion of bioenergetic and genomic capacity over several orders of magnitude permitted a radical solution not available to prokaryotes: cell fusion masked mutations in genes, while doubling the genome enabled cell division despite variable numbers of chromosomes.