Sentence examples for marked mutation from inspiring English sources

Understanding how the causes of cancer, such as aging or smoking, affect tissue microenvironments to control the impact of mutations on somatic cell fitness can help reconcile the discrepancy between marked mutation accumulation starting early in life and the somatic evolution that leads to cancer at advanced ages or following carcinogenic insults.

In addition, parental germplasm and progeny lines used in bi-parental QTL studies (double haploid lines, recombinant lines, near-isogenic lines), functional genomics populations with FSTs marking mutations of interest, and association mapping panels can also be jointly employed for further fine mapping and gene function validation.

The novel, as the critic Lionel Trilling said, marked a mutation in culture: God may have died, but the Devil was flourishing, especially in English public schools.

Note, however, that the over-/under-representations can be made less marked by mutation processes lacking neighbor-base-dependence (we thank R.R. Hudson for pointing this out).

This is because most of the Y-chromosome does not undergo recombination, hence population polymorphism originates only from mutations, and individuals can be placed on a common phylogenetic tree, whose branches are marked by mutations.

This subgroup was marked by mutations of multiple genes that exhibit a mutually exclusive pattern in this cohort (Fig.  4 and in Additional file 1: Figure S4).

A silent restriction site (AvrII in D91N and HindIII in E101Q) was introduced into the mutagenic 5' primer to mark the mutation.

AA change: marked if the mutation site has been sequenced and a mutation changes the amino acid sequence; Annotation: description of the protein.

Marker mutations and balancers are described in flybase (http://flybase.org).org

Interestingly, we also identified a number of mutations and combination of mutations (marked by "a" in Table 2) that are rare or not previously described in the respective tumour types.

The discovery of the JAK2 V617 mutation marked a significant milestone in understanding the pathophysiology of the disease and subsequently the diagnostic and therapeutic approaches.