Sentence examples for mutations is thought from inspiring English sources

The loss of α-MSH-mediated activation in the human MC4R mutations is thought to be the basis of the obesity in patients carrying these mutations.

Second, the underlying mechanism of FTD associated with progranulin mutations is thought to be haploinsufficiency [7], [8], whereas other disease proteins seem to contribute to pathogenesis, at least in part, through toxic gain-of-function mechanisms [14] [17].

The effect of these deleterious mutations is thought to have different consequences for eukaryotic and bacterial genome architecture.

A family reported by Schatz et al. in 2006 [ 32] with compound heterozygous BEST1 mutations is thought by some to have represented ARB rather than 'atypical' BVMD [ 9].

The stability of Jade-1 is dependent on the presence of a functional von Hippel-Lindau (VHL) protein [ 183], downregulation of Jade-1by VHL mutations is thought to be responsible for the hyperactivation of the Wnt pathway in renal cell carcinoma.

Few secondary mutations other than T790M have been identified to date and include D761Y, L747S, and T854A; these non-T790M mutations are thought to occur in <5% of EGFR-mutated TKI-resistant patients 43.

The Ras gene mutations were thought to activate multiple signaling pathways leading to cell proliferation (Maruta & Burgess, 1994).

Because beneficial gene mutations are thought to be exceptionally rare, the scientists postulated that the bugs' speedy adaptation must rely on something else.

Within each class mutations are thought to be sex-specific.

SPINK1 gene mutations are thought to diminish protection against prematurely activated trypsin, and are thereby linked to trypsin-related pancreatic injury [10], [15].

These mutations are thought to increase the amount of Aβ42 polypeptide produced relative to another non-toxic APP cleavage product, the Aβ40 polypeptide.