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Thus, the predicted consequence of FHM1, FHM2, and FHM3 mutations is increased levels of glutamate and potassium in the synaptic cleft (see also Fig. 2).
Compared with a previous profile score that was based on the log-odds likelihood calculation, the correlation between predicted and experimental ΔΔG of single-site mutations is increased in this approach from 0.33 to 0.68.
The total of 26 missense mutations is increased compared to ten previously [ 2].
Peters et al. [ 39] suggested that the explanation for this empirical observation may be that the frequency of mutations is increased in these regions.
In addition, several large multicenter genetic studies have shown the incidence of gba mutations is increased among patients with PD (Anheim et al., 2012; Lesage et al., 2011; Neumann et al., 2009).
At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased.
Similar(53)
The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity.
If the effects of detrimental mutations are increased in the asexual-mutator populations, this will depress fitness gains.
Since, the expression of vitamin D receptor (VDR) in cells with Flt3 mutations was increased to the same extent as in other AML cells this suggests that failure of these cells to differentiate lies downstream of the receptor.
It was found that spontaneous mutations were increased several hundred fold when Mag expression was relatively high and Apn1 relatively low [12], [15].
Thus, driver mutations accrued faster as the deleteriousness of housekeeper mutations was increased (Fig. 6D).
More suggestions(15)
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transfer is increased
mutations is performed
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mutations is known
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mutations is expected
mutations is recommended
mutations is given
mutations is maintained
mutations has increased
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