Sentence examples for mutations is believed from inspiring English sources

Loss of the pVHL tumor suppressor, as occurs with Type 1 VHL mutations, is believed to promote renal tumorigenesis primarily through loss of pVHL-mediated HIF regulation [22].

A complication in these types of association studies is that the vast majority of non-synonymous mutations are believed to be neutral to phenotypes.

The rare class 2 mutations are believed to create a deprotected S2 cleavage site, a model consistent with the observation that these mutations typically produce large, ligand-independent increases in Notch1 signaling activity.

Interestingly, calcium related proteins were found to be downregulated in Duchenne muscular dystrophy where dystrophin mutations are believed to destabilize the major sarcolemma dystrophin-glycoprotein complex which in turn affects sarcolemma integrity and calcium buffering [34], [35].

Splice site mutations are believed to cause several genetic diseases.

Mutations are believed to be the principal mechanism of malignant transformation [ 9].

PIK3CA mutations are believed to be early events in the development of breast cancer [ 61, 69– 71].

These mutations were believed to offset the destabilizing effect of H275Y and possibly enhance virus transmissibility.

KRAS mutations are believed to play an important role in progression towards adenocarcinomas [ 1].

Until recently, IDH1/2 mutations were believed to result in the stabilization of HIF1 α [ 10, 17].

Therefore, these and other common somatic mutations are believed to play a causal role in the etiology of CLL.