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The comparison of clinical characteristics of patients with and without TP53 mutations is shown in Table 2. TP53-mutated patients were older (median, 67 vs 50 years, P=0.0003) and had lower WBC, blast and platelet counts than TP53 wild-type patients (P<0.0001, <0.0001 and 0.0267, respectively).

Summary of Nav1.7 mutations is shown in different gray boxes.

One potential evolutionary route from LinBUT to LinBMI by the accumulation of seven point mutations is shown by arrows (a).

The number of mutations is shown as a function of Avidian genome position, showing that all 50 positions in the genome are subject to mutation.

A schematic representation of the different mutations is shown in Fig. 1B.

Spectrum of PTEN mutations is shown in Figure 1.

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The numbers of the mutated sequences and the mutations are shown below each bar graph.

Seven of the 13 patients with p53 mutations were shown to contain multiple mutated tissue samples.

One of these mutations was shown to increase the risk of heart attack by as much as 29%.

TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation.

For illustration, we apply the RNAMute package on an RNA transcript for which individual point mutations were shown experimentally to inactivate spectinomycin resistance in Escherichia coli.

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