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In contrast, methods based on the differing proportions of non-synonymous and synonymous mutations is considered to be best at detecting selection that acted over a much longer time scale [16].
Nevertheless, if rapid reversion of mutations is considered to reflect the severity of the fitness cost associated with these mutations, our data seem to suggest that CTL escape mutations outside conserved regions may also be associated with a severe fitness cost to the virus.
The search for breast cancer predisposing mutations is considered to be particularly effective in patient series with a pronounced family history of the disease.
Finally, the fluctuation in the levels of ceramide, the result of homozygous or heterozygous GBA mutations, is considered to cause Parkinsonism as well [ 18].
Similar(56)
Thus, these gain of function mutations are considered to result in a constitutively active inflammasome.
Other mutations are considered to be associated with virulence and clinical severity.
Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are considered risk factors for venous thromboembolism.
For the sample with a paired control, acquired mutations were considered when the allele frequency of the variant in the disease sample at least doubled the allele frequency of the variant in the control sample.
BARD1 mutations are considered a high cancer risk and need further examination, as their exact function after mutation is relatively unknown.
Mutations were considered as "not tolerated" when P<0.05.
Intragenic suppressor mutations were considered separate events, and calculated as such.
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