Sentence examples for mutational profiles in from inspiring English sources

Sequencing of 87 genes presented similar mutational profiles in Korean MDS patients compared with previous reports.

Our data on 8- to 11-mer microsatellites was concluded to represent mutational profiles in the quasi-exponential stage.

Molecular epidemiology studies have associated mutational profiles in these genes with specific exposures.

We planned a triple approach based on: i) analysis of immunophenotypes and mutational profiles in a cohort of thoracoscopic MPM samples, ii) in vitro pharmacological assays, ii) in vivo therapeutic approaches on MPM xenografts.

The analysis of mutational profiles in the 'hot spot' regions of EGFR (exons 18 21), KRAS (exon 2), and PIK3CA (exons 9 and 20) genes revealed no somatic mutations in MPM samples (Additional file 1: Table S1).

In theory, whereas NMF is able to highlight true mutational signatures that underlie mutational profiles in cancers, it should be noted that it is also able to identify systematic sequencing artifacts as a mutational signature.

Among CRCs with a PIK3CA mutation, 77% showed concurrent mutations in other cancer-associated genes, and 4% of CRC did not neatly fit into either the chromosomal instability pathway or CpG island methylator phenotype/microsatellite instability pathway, suggesting overlapping mutational profile in some tumors.

It will be important to learn more about the function of this gene and its potential mutational profile in breast cancer.

Our study has limitations, including a small sample size that limits our ability to calculate the diagnostic performance of mutational profiling in pancreatic masses and associated biliary strictures.

Because variations in the frequency of EGFR-activating mutations in East Asians and other patients with lung cancer have been described, we evaluated the EGFR mutational profile in tumour samples from European patients with TNBC.

In contrast, when the mutational profile in follow up biopsies differs from that of the initial biopsy, new clones of cells, as identified by different mutations, have likely evolved.