In 2005, a landmark discovery identified a gain of function mutation, JAKV617F, as being an essential mutational driver in many MPNs.
The low frequency of recurrent mutations and the little overlap of mutated genes (except EGFR) across the studies may suggest the mutational drivers for lung cancer in never smokers can be diverse and highly individualized.
Current models of cancer propagation or 'stem' cells pay scant attention to the evolutionary dynamics of cancer or to the underlying genetic, mutational drivers.
This catalog of mutational drivers included 459 genes.
- However, there are only a few GBM mutational "drivers," suggesting that we may have to expand our search for "drivers" beyond somatic mutations to understand the genomic networks misregulated in GBM.
The list of drivers employed in this study in each tumor type (and by extension the driver TFs) are known to be expressed in the tumors of the cohort where they act as drivers, because part of the process of detection of mutational drivers excludes non-expressed genes.
Further, knowledge of the molecular pathways and mutational drivers of lung cancer will expand the use of targeted treatments.
The activity of some TFs as mutational drivers is very specific of one or few tumor types.
This work presents the first systematic characterization of the repertoire of mutational driver transcription factors in 28 human malignancies, as well as the collection of their targets most likely involved in tumorigenesis in 15 of these cancer types.
The 20-20 rule was created to identify mutational driver genes, both oncogenes and tumor suppressor genes (Vogelstein et al., 2013).
