Sentence examples for mutational processes in from inspiring English sources

In this review, we summarize recent whole genome and/or whole exome genomic studies, and then put these findings in the context of genetic hallmarks of somatic mutations and mutational processes in human osteosarcoma.

Analysis of such mutations allows us to better understand the mutational processes in normal cells, explore cell lineages in development, and examine potential associations with age-related disease.

Using a reductionist model that mimics the role of random mutational processes in the emergence of biodiversity, this board game is a device for initiating and training students in the study of DNA and its relation to evolution.

Additionally, I participated in mapping the signatures of the somatic mutational processes in human mitochondria (22) as well as in understanding the mutational processes operative in normal somatic cells (23, 24).

I started by conceptualizing the problem and developing a mathematical model that describes the interconnection between the activity of mutational processes in cancer cells and the mutational catalogs generated by next-generation sequencing of cancer genomes (6).

They likely represent another process than the regular mutational processes in DNA.

This may be adequate when a single mutational process generates the majority of mutations in the particular cancer (e.g. UV light is the predominant mutational process in melanoma [ 19 ]).

However, where there is heterogeneity of mutational process in a cancer class, a composite of different processes will be reported.

The strength of exposure of a mutational process in a set of genomes also influences the ability to decipher its signature.

One of the major mutational processes that impact the GC content along the genome is methylation of cytosines that are part of CpGs, which is by far the strongest mutational process in the mammalian genomes [ 14].

This approach integrates biological knowledge of the mutational process in tumors and uses a heuristic strategy to optimize the mixture proportion of chi-square distribution of likelihood ratio test (LRT) statistics.