Sentence examples for mutational alterations in from inspiring English sources

The molecular mechanisms underlying taxane resistance involve mutational alterations in the tubulin subunits, microtubule dynamics, phenotyping programming of the epithelial-to-mesenchymal transition landscape, and the status of AR activity.

RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44.

The recent reports on the interplay of S12 on 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides prompted us to study in detail the role, if any, between RpsL K42R and mutational alterations in 16S rRNA helix 44 conferring resistance to 2-deoxystreptamines.

The function of this domain is unknown, but mutational alterations in this loop affect the localization of MalK Ec to the membrane bound MalF Ec [ 29].

Therefore, in order to obtain data on the relevance of the Ras-homologous GTPases in the formation and progression of breast carcinomas, we analysed Rho proteins as to mutational alterations in tumours.

Genetic screening of cell lines did not reveal any mutational alterations in the SIP1 gene, suggesting the implication of epigenetic regulatory mechanisms for the silencing of SIP1 in HCC.

Here, we have analysed the coding sequence of TP53 in a series of brain metastases, confirmed by histopathology to derive from primary breast carcinomas, and we report a high frequency of TP53 mutational alteration in breast cancer metastatic to the brain.

No mutational alterations were observed in plasmids sequenced after expression.

In this report, we describe the establishment of primary mesothelioma cultures and patient derived tumor xenografts with mutational alterations that recapitulate those in the original patient tumors.

This became obvious when the group analysed distinct fragments of the original lesion and obtained different results regarding the mutational alterations that were detectable in these biopsies (Fig 1).

We therefore performed mutational alterations of the positive charges in the putative S4 segment of Ci-VSP with the aim of shifting the voltage dependency to a more physiological region.