Sentence examples for mutational process in from inspiring English sources

This may be adequate when a single mutational process generates the majority of mutations in the particular cancer (e.g. UV light is the predominant mutational process in melanoma [ 19 ]).

However, where there is heterogeneity of mutational process in a cancer class, a composite of different processes will be reported.

The strength of exposure of a mutational process in a set of genomes also influences the ability to decipher its signature.

One of the major mutational processes that impact the GC content along the genome is methylation of cytosines that are part of CpGs, which is by far the strongest mutational process in the mammalian genomes [ 14].

This approach integrates biological knowledge of the mutational process in tumors and uses a heuristic strategy to optimize the mixture proportion of chi-square distribution of likelihood ratio test (LRT) statistics.

Questions regarding the origins of genomes have direct implication for our understanding of the roles of gene families, duplication and deletion of segments of genomes, and the mutational process in human health and disease.

In this review, we summarize recent whole genome and/or whole exome genomic studies, and then put these findings in the context of genetic hallmarks of somatic mutations and mutational processes in human osteosarcoma.

Analysis of such mutations allows us to better understand the mutational processes in normal cells, explore cell lineages in development, and examine potential associations with age-related disease.

Alexandrov, L. B. et al. Clock-like mutational processes in human somatic cells.

Alexandrov, L. B. et al. Signatures of mutational processes in human cancer.

Alexandrov, L.B. et al. Signatures of mutational processes in human cancer.