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These results indicated that overproduction of either DbpA or DbpB is unable to restore the ability of the dbpAB mutant to maintain the bacterial load in either heart or joint tissue.

Presumably, flexibility in the resulting contact allows the N255K mutant to maintain affinity for microtubules even when the switch loops are open.

We observe a surprising ability of the mutant to maintain nutrient homeostasis, but demonstrate a major defect in maintaining sufficient levels of the macronutrient potassium.

It seems that the additional sites in the heteromers helped the mutant to maintain the correct quaternary structure under physiological conditions.

Significant transcriptional upregulations of cysteine and glutathione synthesis and concomitant stimulations of glutathione-mediated antioxidant defense helped rlfL-1 mutant to maintain balanced reactive oxygen species (ROS) metabolisms, as deduced by ROS-imaging study.

The major difference observed biochemically between the wild type and P45L cdk2 proteins was the reduced ability of the mutant to maintain association with its cognate cyclin over prolonged periods.

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Similar(52)

The dramatic inability of the prkaca-L173A and prkaca-F327A mutants to maintain viability in the tpk null strain may indicate that residues that undergo structural rearrangement may play a more significant role in regulating nucleotide binding for PKA activity.

These features allow the mutants to maintain the peroxidase activity required for virulence, and to resist killing by isoniazid.

We performed additional experiments in YEPD medium testing the potential requirement for AAC2 deletion in the ability of fzo1 ∆ PDR1 -249 mutants to maintain mtDNA.

All of these approaches focus on a single input sequence and the ability of its neighboring mutants to maintain a "wild-type" structure.

Redundancy in the GA20ox genes might maintain GA homeostasis in all organs except the growing inflorescence stem and leaves, thus allowing ga5 mutants to maintain a root system similar to that of the corresponding wild types.

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