Sentence examples for mutant to klotho from inspiring English sources

We thus submitted the daf-16 (mgdeletionletion mutant to klotho RNAi.

We investigated the involvement of PI3-kinase/AGE-1 in worms by submitting the strong loss-of-function allele age-1 mg44) age-1 mg44klotho knockdown.

However, since this negative lifespan modulation vanished when daf-2, age-1 or daf-16 mutants were submitted to klotho knockdown, we propose that Klotho de-represses DAF-16 by constitutively down-regulating DAF-2.

To generate fls2 double-1 double mutant, single mutant fls2 was crossed with desi3a-1 single mutant to generate fls2 double-1 double mutant.

When it comes to Klotho, there may be no such line.

Our studies show that Klotho also stimulates the nuclear translocation of Nrf2 adding the multiple anti-oxidant genes regulated by the ARE to Klotho's function that confers resistance to oxidative stress.

These data suggest that the physiological responses to Klotho ablation and overexpression may activate specific signaling processes unique to Klotho function and raises the question of whether genes targeted by these differential responses play a role in longevity determination.

Therefore, klotho-upregulated autophagy flux may be attributable to klotho-mediated renoprotection.

Binding of FGF23 to ubiquitously expressed FGF receptors (FGFR) requires Klotho as an obligatory co-receptor (Kurosu et al, 2006; Urakawa et al, 2006), restricting the hormonal action of FGF23 to Klotho-expressing tissues.

The C. elegans genome contains two sequences homologous to the mammals klotho gene : C50F7.10 and E02H9.5.

Additionally, miR-199a-5p did not alter activity of the mutant klotho luciferase reporter, and specifically acted on wild-type klotho 3′-UTR.